Rezende.

Chagas disease (CD) is recognized as one of the 20 neglected tropical diseases by the World Health Organization (WHO), posing a significant global health challenge. The objective of this work was to conduct a systematic methodology review to explore the different classifications used to describe the presence and degree of organ involvement in patients with CD since the disease’s description in 1909. We searched relevant electronic medical databases from their inception dates to July 2023. We also delved into historical variations and revisions of each classification, the necessary diagnostic methods, their prognostic value, and their uptake. Our study underscores the conspicuous absence of a universally accepted CD classification system for cardiac and digestive involvement, both in the context of clinical trials and within current clinical guidelines. This endeavour will facilitate cross-population comparisons if clinical manifestations and complementary test results are available for each patient, constituting a pivotal stride toward identifying precise prognoses and establishing a minimum data set requisite for a fitting CD classification, tailored to the test availability in both endemic and non-endemic regions.查加斯病（Chagas disease，CD）被世界卫生组织（WHO）列为20种被忽视的热带病之一，构成重大全球公共卫生挑战。本研究旨在开展系统方法学综述，探究自1909年查加斯病首次被报道以来，用于描述患者器官受累情况及其程度的各类分类体系。研究检索了各电子医学数据库自建库至2023年7月的相关文献，同时梳理了各类分类体系的历史演变与修订版本、所需配套诊断方法、预后价值及临床采纳与应用情况。本研究表明，无论是在临床试验场景还是现行临床指南中，目前均缺乏被广泛认可的查加斯病心脏与消化道受累分类体系。若能获取每位患者的临床表现与辅助检查结果，本研究成果将有助于开展跨人群比较，为明确精准预后、构建适配流行区与非流行区检测资源条件的标准化查加斯病分类体系所需的最小数据集（minimum data set）迈出关键一步。