Cholesterol-dependent control of endosomal escape regulates intracellular trafficking of small interfering RNA therapeutics and interactions with small molecule drugs

This dataset includes raw and processed measurements examining how modulation of intracellular cholesterol alters the efficacy of FDA-approved siRNA therapeutics. Data are structured according to experimental variables, including cell model, cholesterol manipulation strategy, siRNA treatment, and target suppression quantified at both the mRNA and protein levels.

本数据集包含原始与经处理的测量数据，旨在探究细胞内胆固醇的调控如何改变美国食品药品监督管理局（Food and Drug Administration，FDA）批准的小干扰RNA（small interfering RNA，siRNA）疗法的疗效。数据按照实验变量进行结构化组织，涵盖细胞模型、胆固醇调控策略、siRNA处理方案，以及在信使RNA（messenger RNA，mRNA）和蛋白质水平上量化得到的靶基因抑制效果。