Profiling epididymal white adipose tissue (eWAT) from obese db/db and lean control db/+ mice. Mus musculus

This program addresses the gene signature associated with the development of type 2 diabetes in the db/db mice. Specifically, which genes are differentially expressed in adipose tissue of the db/db mice compared to the control db/+ mice? Overall design: The db/db mice eWAT profiling data was analyzed by identifying genes that were up- and down-regulated at selected p value and fold change in the eWAT of db/db mice compared to the corresponding db/+ controls.

本分析方案聚焦于db/db小鼠中与2型糖尿病（type 2 diabetes）发生发展相关的基因特征。具体而言，相较于对照db/+小鼠，db/db小鼠脂肪组织内存在哪些差异表达基因？实验设计：本研究通过筛选相较于对应db/+对照小鼠，db/db小鼠附睾白色脂肪组织（eWAT）中符合预设P值（p value）与倍数变化（fold change）阈值的上调与下调基因，对db/db小鼠eWAT的表达谱数据开展分析。