Number of true genes identified as a function of proportion of pathogenic mutations that are type TSJ.
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pTSJ: proportion of pathogenic mutations that are type TSJ; Np: number of pedigrees in stage I; Ns: number of individuals sequenced per pedigree in stage I. nTrue: number of true susceptibility genes passed to the validation in stage II; cost is in 100k USD.aCost does not vary with pTSJ, therefore the number should be equal to that for Filter = N1TS pTSJ = 0.5. Filters are described in Table 2.
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2015-12-02



