Cascade Synthesis of 3‑Alkylidene Dihydrobenzofuran Derivatives via Rhodium(III)-Catalyzed Redox-Neutral C–H Functionalization/Cyclization

An
efficient rhodium­(III)-catalyzed coupling reaction of N-phenoxyacetamides with propargyl carbonates to yield 3-alkylidene
dihydrobenzofuran derivatives via C–H functionalization/cascade
cyclization has been developed. This transformation represents a redox-neutral
process and features the formation of three new bonds under mild conditions.

本研究开发了一种高效的铑(III)催化N-苯氧基乙酰胺与炔丙基碳酸酯的偶联反应，该反应通过C-H键官能团化/级联环化路径生成3-亚烷基二氢苯并呋喃衍生物。该转化属于氧化还原中性过程，且可在温和条件下实现三个全新化学键的构建。