Body Mass Index and Polycystic Ovary Syndrome: A Two-sample Bidirectional Mendelian Randomization Study

Observational studies have shown a link between
elevated body mass index (BMI) and the risk of polycystic ovary syndrome
(PCOS). While Mendelian randomization (MR)
studies in Europeans
have suggested a causal role of increased BMI in PCOS, whether the same role is
suggested in Asians has yet to be investigated. We used MR studies to infer causal effects using
genetic data from East Asian populations.

观察性研究已证实，体质量指数（body mass index, BMI）升高与多囊卵巢综合征（polycystic ovary syndrome, PCOS）的发病风险存在关联。尽管针对欧洲人群的孟德尔随机化（Mendelian randomization, MR）研究提示，BMI升高在PCOS的发病中发挥了因果作用，但这一因果效应是否同样存在于亚洲人群中仍有待探究。本研究借助东亚人群的遗传数据，通过孟德尔随机化研究方法推断BMI与PCOS之间的因果效应。