35th Multicenter Airway Research Collaboration (MARC-35): EWAS analysis of infants

In a multicenter prospective cohort study of infants hospitalized with bronchiolitis, we profiled their epigenome-wide blood DNA methylation level at hospitalization using Infinium MethylationEPIC BeadChip. We found that blood DNA methylation signatures were associated with bronchiolitis severity and various respiratory and immune traits.本项针对因细支气管炎住院的婴幼儿开展的多中心前瞻性队列研究中，我们采用Infinium MethylationEPIC BeadChip芯片，对受试者住院时的全表观基因组血液DNA甲基化水平进行了表征分析。研究发现，血液DNA甲基化特征与细支气管炎严重程度及多种呼吸、免疫性状存在关联。