A New Multicomponent Multicatalyst Reaction (MC)2R: Chemoselective Cycloaddition and Latent Catalyst Activation for the Synthesis of Fully Substituted 1,2,3-Triazoles

A multicomponent multicatalyst reaction (MC)2R for constructing fully substituted 1,2,3-triazoles is reported. An application of chemoselectivity and latent catalysis in a sequence of multicatalytic reactions confers control over a number of undesired processes, where all of the reagents coexist in the same reaction vessel. The sequence of a chemoselective copper-catalyzed azide alkyne cycloaddition followed by a palladium/copper-catalyzed Sonogashira cross-coupling afforded 1,2,3-triazoles regioselectively with good to high yields and a broad scope.本研究报道了一种可用于构建全取代1,2,3-三氮唑的多组分多催化剂反应（MC2R）。该反应通过在多催化串联序列中应用化学选择性与潜伏催化策略，实现了对多种副反应的精准调控，使得所有反应物可共存于同一反应容器中。具体而言，先经化学选择性铜催化叠氮-炔环加成（copper-catalyzed azide alkyne cycloaddition），再进行钯/铜协同催化的Sonogashira交叉偶联反应（Sonogashira cross-coupling），该串联反应可区域选择性地得到1,2,3-三氮唑产物，且具有良好至高的产率与宽泛的底物适用范围。