DEDD regulates cell cycle related genes

In DEDD knocked-down triple-negative breast cancer, cell cycle related gene expressions have been altered Overall design: We transfected a TNBC cell line MDA-MB-468 with anti-DEDD shRNA to study DEDD dependent transcriptome changes在DEDD基因敲低的三阴性乳腺癌（triple-negative breast cancer, TNBC）模型中，细胞周期相关基因的表达发生了改变。实验设计：我们向三阴性乳腺癌细胞系MDA-MB-468中转染靶向DEDD的短发夹RNA（short hairpin RNA, shRNA），以研究依赖DEDD的转录组变化。