Hemodynamic parameters.

Background To compare the effects of preemptive single-dose intravenous (IV) ibuprofen and dexketoprofen on postoperative pain and opioid consumption in patients undergoing laparoscopic cholecystectomy (LCC). Methods The study included 90 patients aged 18–65 years with an ASA score of I or II who underwent LCC. Patients were equally divided into three groups: Control Group (Group P), 100 cc 0.9% NaCl was infused intravenously over 30 min, Dexketoprofen Group (Group D), 50 mg dexketoprofen in 100 cc 0.9% NaCl was infused intravenously over 30 min, and Ibuprofen Group (Group I), 800 mg ibuprofen in 100 cc 0.9% NaCl was administered intravenously over 30 min. Visual Analog Scale (VAS) scores and opioid requirement were recorded at 1, 2, 4, 6, 12 and 24 hours postoperatively. Results There was no significant difference between the Dexketoprofen and Ibuprofen groups with regard to VAS scores, whereas VAS scores were higher in the control group than other groups in the 1st, 2nd, 4th, 6th,12th, and 24th hours. In addition, fentanyl consumption was higher in the control group at 0–6 hours and at 24 hours compared to the other two groups. Conclusion Preemptive ibuprofen and dexketoprofen administration reduce pain scores and opioid consumption compared with the control group, however, they are non-inferiority to each other.背景：本研究旨在对比术前单次静脉输注（intravenous, IV）布洛芬与右酮洛芬，对接受腹腔镜胆囊切除术（laparoscopic cholecystectomy, LCC）患者的术后疼痛及阿片类药物消耗量的影响。 方法：本研究纳入90例年龄18~65岁、美国麻醉医师协会（ASA）分级为I或II级且接受腹腔镜胆囊切除术的患者。将患者随机均分为三组：对照组（P组）：经静脉输注100 mL 0.9%氯化钠溶液（NaCl），输注时长30分钟；右酮洛芬组（D组）：将50 mg右酮洛芬溶于100 mL 0.9%氯化钠溶液中，经静脉输注30分钟；布洛芬组（I组）：将800 mg布洛芬溶于100 mL 0.9%氯化钠溶液中，经静脉输注30分钟。分别于术后1、2、4、6、12及24小时记录视觉模拟评分（Visual Analog Scale, VAS）及阿片类药物使用需求量。 结果：右酮洛芬组与布洛芬组的VAS评分无显著差异；而在术后1、2、4、6、12及24小时，对照组的VAS评分均高于其余两组。此外，对照组在术后0~6小时及24小时的芬太尼消耗量均高于另外两组。 结论：与对照组相比，预防性给予布洛芬或右酮洛芬均可降低术后疼痛评分与阿片类药物消耗量，且二者镇痛效果无显著差异。