Botox injection in Refractory Overactive Bladder: Sacral Neuromodulation v. Botulinum Toxin Assessment

Botox injection variables for participants randomized to Botox, SAS Study Description The purpose of this randomized, open-label, active-control trial was to compare the effectiveness of intra-detrusor botulinum toxin A (Botox A®, Allergan) versus sacral neuromodulation (InterStim®, Medtronic) for the treatment of refractory urge urinary incontinence. In addition, the study evaluated select technical attributes of the interventions as well as the effect of these two interventions on other lower urinary tract and pelvic floor symptoms. Non-pregnant adult females at least 21 years old with refractory urinary urge incontinence用于随机分配至肉毒杆菌毒素（Botox）、骶神经调节（sacral neuromodulation，SAS）组受试者的肉毒杆菌注射变量 研究描述 本项随机、开放标签、阳性对照试验旨在比较膀胱壁内注射A型肉毒杆菌毒素（Botox A®，艾尔健Allergan）与骶神经调节（InterStim®，美敦力Medtronic）治疗难治性急迫性尿失禁的临床有效性。此外，本研究还评估了两种干预措施的选定技术属性，以及二者对其他下尿路及盆底症状的影响。本研究纳入的受试者为年龄≥21岁的非妊娠成年女性，且患有难治性急迫性尿失禁