Expression of dTip60^E431Q using the pan-neuronal elav-GAL4 driver leads to lethality.

*p≤0.05. aTest Cross Fly Lines. Five male flies homozygous for either dTip60E431Q or dTip60WT P-element insertions or control w1118 were mated to 10 female virgin flies homozygous for the pan-neuronal elav-GAL4 driver located on chromosome X. Adult progeny were counted over an eight day period and the total male (GAL4−) and female (GAL4+) numbers were scored. bNumber of Surviving Flies. Both dTIP60E431Q lines showed significant lethality, with 25% survival for line A and 0% survival for line B and C. Both dTIP60WT lines showed no observable phenotypic effects. The results are reported as mean ± SD, (n = 3).*p≤0.05。 a 果蝇测交实验品系：将5只分别携带纯合dTip60E431Q、dTip60WT P因子（P-element）插入片段，或对照品系w1118的雄性果蝇，与10只纯合X染色体上泛神经元elav-GAL4驱动子的处女雌果蝇进行交配。在8天的周期内统计子代成虫数量，分别记录雄性（GAL4−）与雌性（GAL4+）的总个体数。 b 存活果蝇计数：两个dTIP60E431Q品系均表现出显著致死效应，品系A的存活率为25%，品系B与C的存活率为0%；两个dTIP60WT品系均未观察到可检测的表型变化。实验结果以平均值±标准差（mean ± SD）表示，样本量n=3。