FAIRsharing record for: Library of Integrated Network-Based Cellular Signatures Data Portal

This FAIRsharing record describes: The LINCS Data Portal provides a unified interface for searching LINCS dataset packages and reagents. LINCS data are being made openly available as a community resource through a series of data releases, so as to enable scientists to address a broad range of basic research questions and to facilitate the identification of biological targets for new disease therapies. LINCS datasets consist of assay results from cultured and primary human cells treated with bioactive small molecules, ligands such as growth factors and cytokines, or genetic perturbations. Many different assays are used to monitor cell responses, including assays measuring transcript and protein expression; cell phenotype data are captured by biochemical and imaging readouts. Assays are typically carried out on multiple cell types, and at multiple timepoints; perturbagen activity is monitored at multiple doses.

本FAIRsharing记录所描述的内容如下：LINCS数据门户（LINCS Data Portal）提供了统一的检索界面，用于检索LINCS数据集套件与相关试剂。LINCS数据正通过多轮数据发布以社区共享资源的形式开放获取，以期助力科学家解决广泛的基础研究问题，并推动新型疾病治疗相关生物学靶点的识别。LINCS数据集涵盖经生物活性小分子、生长因子与细胞因子等配体，或遗传扰动处理的培养细胞与原代人细胞的检测实验结果。研究采用多种检测手段监测细胞应答，包括转录本与蛋白质表达量检测；细胞表型数据通过生化检测与成像读值进行采集。检测实验通常在多种细胞类型与多个时间点下开展，扰动因子的活性则通过多剂量梯度进行监测。