LEARN Registry Manuscript Data for Sharing.

Improving neonatal resuscitation practices reduces neonatal mortality. In low- and middle-income countries (LMICs), granular details about provider actions during resuscitation are largely unknown; therefore, identifying targets for improvement is difficult. The International Liaison Committee on Resuscitation (ILCOR) recognizes the importance of uniform reporting of clinical neonatal resuscitation studies and published a guideline recommending specific variables to include. We established an open cohort study for newborn resuscitation in the Democratic Republic of the Congo (DRC) as a platform for developing and evaluating novel strategies to improve newborn resuscitation. We included all in-born neonates at two health facilities in Kinshasa, DRC. We gathered data on all enrollees via delivery registry and medical record abstraction. Using the Liveborn Observation app, we directly observed care at birth for a convenience sample. We collected heart rate data when providers used NeoBeat, a battery-operated heart rate meter. From September 2022 to August 2023, we abstracted delivery registry and medical record data for 6,414 newborns and gathered observational data on the infant’s breathing status and provider actions for 3,166 (49%). Our dataset includes 85% of ILCOR’s recommended core variables applicable to this setting, and 50% of ILCOR’s applicable supplemental variables. Our registry also contains variables beyond those recommended by ILCOR that are contextually important for evaluating resuscitation care in LMICs such as duration of suctioning, pauses in positive pressure ventilation and fresh stillbirth. Our experience establishing a resuscitation registry with novel tools in the DRC serves as a model for resuscitation research in low-resource settings. Our cohort study provides important insight to inform subsequent versions of ILCOR’s guideline on uniform reporting of neonatal resuscitations studies globally.优化新生儿复苏操作可降低新生儿死亡率。在低收入和中等收入国家（low- and middle-income countries, LMICs），复苏过程中医护人员操作的精细化细节大多尚不明确，因此难以确定改进目标。国际复苏联合委员会（International Liaison Committee on Resuscitation, ILCOR）认识到临床新生儿复苏研究统一报告的重要性，并发布了指南，推荐需纳入的特定变量。我们在刚果民主共和国（Democratic Republic of the Congo, DRC）开展了一项新生儿复苏开放队列研究，作为开发和评估优化新生儿复苏新策略的研究平台。我们纳入了刚果民主共和国金沙萨两家医疗机构的所有院内分娩新生儿。我们通过分娩登记系统和病历摘录收集所有入组对象的数据。我们借助Liveborn Observation应用程序，对便利抽样样本的出生照护过程进行了直接观察。当医护人员使用NeoBeat（一款电池供电的心率检测仪）时，我们收集了心率数据。2022年9月至2023年8月期间，我们为6414名新生儿提取了分娩登记和病历数据，并为其中3166名（占比49%）收集了关于婴儿呼吸状况及医护人员操作的观察数据。本数据集涵盖了适用于该场景的85%的ILCOR推荐核心变量，以及50%的ILCOR推荐适用补充变量。本登记系统还包含了ILCOR未推荐但在评估低收入和中等收入国家复苏照护时具有重要场景意义的变量，例如吸痰时长、正压通气暂停时长以及新鲜死胎相关数据。我们在刚果民主共和国借助新型工具搭建复苏登记系统的经验，可为低资源环境下的复苏研究提供参考范式。本队列研究可为后续全球新生儿复苏研究统一报告的ILCOR指南修订提供重要参考依据。