ERG-mediated coregulator complex formation maintains androgen receptor signaling in prostate cancer [PolII ChIP]

We report the effects of ERG on prostate tumorigenesis, ERG-mediated oncogene addiction, and downstream AR signaling pathways. We determined that ERG facilitates AR-signaling and mediates transformation of prostate cells by maintaining coregulator complex formation at AR-bound sites across the genome. Overall design: We measured changes in multiple chromatin, transcription factor binding, and transcriptomic profiles from genetic alterations of Pten and ERG murine prostate organoids

本研究报道了ERG在前列腺肿瘤发生、ERG介导的癌基因成瘾以及下游雄激素受体（AR）信号通路中的调控效应。本研究证实，ERG可通过维持全基因组范围内AR结合位点处的辅调控复合物形成，进而促进AR信号通路活化，并介导前列腺细胞的恶性转化。实验设计概述：本研究对经Pten与ERG基因修饰的小鼠前列腺类器官开展了多维度检测，涵盖染色质谱、转录因子结合谱以及转录组谱的变化。