Additional file 9: of Motifome comparison between modern human, Neanderthal and Denisovan

List of human specific motifs for motif lengths 6–10 from core, proximal, distal promoters and introns as compared to Denisovan. Statistically significant motifs of lengths 6–10 from core, proximal, and distal promoters as well as introns unique to modern humans are listed (and not found in Denisovan). These motifs were found in the corresponding genomic subregion in modern human, and the number of such human-unique motifs were listed for each gene variant. From these lists the top 100 genes were selected which had the highest number of human-unique motifs in their promoter/intron. Listed in tab “top genes (based on promoters)” are genes which were found in at least three top 100 lists. This was done separately for core, proximal, and distal promoters, and also for introns in the tab “top genes (based on introns)”. Fifty gene variants (38 genes) were found which both in the proximal and distal promoter sets appeared. One hundred four genes (their NP id, GeneCard name and annotation) were found which were listed in at least 3 top 100 gene lists whose introns contained statistically significant human-unique intron motifs. (XLSX 5181 kb)本数据集收录了相较于丹尼索瓦人（Denisovan）的人类特异性基序（motif）列表，涉及长度为6至10的基序，来源涵盖核心启动子（core promoter）、近端启动子（proximal promoter）、远端启动子（distal promoter）及内含子区域。本列表收录了现代人类独有的、长度为6至10的上述区域内具有统计学显著性的基序——此类基序未在丹尼索瓦人中检出。上述基序均在现代人类的对应基因组亚区域中被检出，本数据集同时统计了每个基因变异体所携带的人类独有基序数量。基于上述统计结果，我们筛选出在其启动子/内含子区域中人类独有基序数量最多的前100个基因。在"基于启动子的核心基因"工作表中，列出了至少出现在3个前100基因列表中的基因；该筛选分别针对核心启动子、近端启动子、远端启动子独立完成，而内含子区域的筛选结果则收录于"基于内含子的核心基因"工作表中。共有50个基因变异体（对应38个独立基因）同时出现在近端启动子和远端启动子的前100基因列表中。另有104个基因（包含其NP登录号、GeneCard名称及功能注释），其内含子区域携带具有统计学显著性的人类独有内含子基序，且至少出现在3个前100基因列表中。本数据集文件格式为XLSX，大小为5181 KB。