Electrochemical Bisarylation of Carbonyls: A Direct Synthetic Strategy for Bis(indolyl)methane

An interesting electrochemical direct bisarylation of carbonyls with indole derivatives to afford the corresponding bis(indolyl)methane (BIM) derivatives is described. The developed protocol is suitable for aliphatic, aromatic, and heteroaromatic aldehydes, which react with various electron-rich and electron-poor indoles to afford the corresponding BIMs in good to excellent yields. Isatin derivatives also underwent bisarylation with various indole derivatives under the influence of current to afford the corresponding BIMs in excellent yields.本研究报道了一种极具应用价值的羰基化合物与吲哚衍生物的电化学直接双芳基化反应，可制备得到相应的双吲哚甲烷（bis(indolyl)methane, BIM）类衍生物。所开发的合成方法适用于脂肪族、芳香族及杂芳香族醛类底物，该类底物可与各类富电子或缺电子吲哚衍生物发生反应，以良好至优异的收率得到对应的BIM产物。靛红（Isatin）衍生物在电流介导下，同样可与各类吲哚衍生物发生双芳基化反应，并以优异收率得到相应的BIM产物。