Data from: Reward-induced phasic dopamine release in the monkey ventral striatum and putamen

Voltammetric recordings of behaving monkeysEach folder contain data files of one experimental day. Original COLOR.txt files. Each FSCV recording consists of 500 voltage points for 10ms (50kHz sampling). Recording was repeated at 10Hz, every 0.1s. In MFB stimulation, each trial was made for 20s (200 time points) and the electrical stimulation was delivered from 5s (from recording 50). Original COLOR data of MFB stimulation is a table of 200 x 500. In behavioral analysis, each recoring was made for 300s block (3000 time points), simultaneously for 4 channels. In most cases, Ch0:ventral striatum (acc, Cd), Ch1:putamen, Ch3:CS signal and Ch4:IR sensor monitoring the facial movement. To export full waveform data of multi-channel recording on TH-1, backgound subtraction was turned off. The original data, recorded as nA value, was exported as COLOR.txt files. Original COLOR data of behavioral task is a table of 3000 x 500. CS signal was simultaneously recorded on Ch2, and the CS timing during 300s block was exported as IT.txt files. The hight of CS signal indicate the type of trials, and the offset of CS is the timing of juice delivery. For free trials, similar timing signal is recorded and the juice was delivered at the offset of the signal, but no visual stimuli appeared on the screen. Original ITCS data of CS is a table of 3000 x 1. For food trials, the pulses in ITCS data indicate the timing of reaching of the food to the mouth. These data were loaded on MATLAB, background subtracted for each trials, and PCR was performed using princomp function. Templates for Principle Component Regression (PCR) analysis. Voltage-current curves (500 points) at the peak MFB responses were collected as in-vivo dopamine template. Also, presumably pH curves were collected 10-15s after the stimulation. PCR results Result of PCR: 1zz, 2zz and 3zz files, each columns indicate one trial for 8s (80 points). Each column started with the Block number, timing point of CS onset in the block and hight of CS signal. The trials judged as "extreme" have more than 1000 value of CS signal. 1zz is the dopamine-like component and 2zz is the pH-like component. 3zz is the current at the peak of dopamine oxidation potential (120/500 points) Point 40 is the CS onset. Timing cue was shown from point 30, and the onset of juice delivery was point 55. One behavioral session consists of multiple 5-min blocks. Review on EXEL show the average of each trial type within the session. In original analysis to calculate PCR result of 1zz, timing of the trials were aligned by CS onset, so time 0 is the time just before the CS onset. For final graph presentation of the results, the timing of juice delivery/CS offset is shown as time 0. In some review tables of EXEL, you need to find which timing determination is applied.YoshimiPlosTXTData-noJP.zip

清醒猴伏安记录数据集。每个文件夹包含单一日实验的数据文件，原始数据格式为COLOR.txt。每次快速扫描循环伏安法（Fast-Scan Cyclic Voltammetry, FSCV）记录包含10ms内的500个电压点，采样率为50kHz，记录以10Hz频率重复，即每0.1秒执行一次。在内侧前脑束（Medial Forebrain Bundle, MFB）刺激实验中，单次试次时长为20秒（对应200个时间点），电刺激于第5秒时开始，即从第50个记录点开始施加，MFB刺激实验的原始COLOR数据为200×500的表格。行为学分析环节中，单次记录为300秒的区块（对应3000个时间点），同时采集4个通道的数据；多数情况下，通道0对应腹侧纹状体（伏隔核acc、尾状核Cd），通道1对应壳核，通道3为条件刺激（Conditioned Stimulus, CS）信号，通道4为监测面部运动的红外传感器信号。若要导出TH-1设备上多通道记录的完整波形数据，需关闭背景扣除功能。以纳安（nA）为单位记录的原始数据将被导出为COLOR.txt格式文件，行为任务的原始COLOR数据为3000×500的表格。条件刺激（CS）信号同时在通道2上采集，300秒区块内的CS时间信息将被导出为IT.txt文件；CS信号的高度代表试次类型，而CS信号的偏移时刻即为果汁递送的时间点。对于自由试次，会记录类似的时间信号，果汁同样在信号偏移时刻递送，但屏幕上不会呈现视觉刺激，CS的原始ITCS数据为3000×1的表格。对于进食试次，ITCS数据中的脉冲代表食物到达口中的时刻。此类数据将在MATLAB中加载，对每个试次进行背景扣除，并通过princomp函数执行主成分回归（Principal Component Regression, PCR）分析。主成分回归（PCR）分析所用的模板包括：采集内侧前脑束刺激峰值处的电压-电流曲线（共500个点）作为活体多巴胺模板，此外推测刺激后10-15秒采集的曲线为pH相关曲线。主成分回归（PCR）结果包含1zz、2zz及3zz文件，每个列对应一个8秒时长的试次（对应80个时间点），每一列的开头依次为区块编号、该区块内CS起始的时间点以及CS信号的高度。被判定为“极端”的试次，其CS信号值大于1000；其中1zz代表多巴胺类成分，2zz代表pH类成分，3zz代表多巴胺氧化电位峰值处的电流，对应第120/500个时间点。第40个时间点为CS起始时刻，时间提示于第30个时间点开始呈现，果汁递送的起始时刻为第55个时间点。一次行为学实验会话包含多个5分钟的区块，通过Excel可查看该会话内每种试次类型的平均值。在最初计算1zz的PCR结果时，试次时间以CS起始时刻对齐，因此时间0即为CS起始前的时刻；若要以最终结果绘图展示，则将果汁递送时刻/CS信号偏移时刻设为时间0。在部分Excel查看表格中，需明确所采用的时间对齐方式。数据集压缩包为YoshimiPlosTXTData-noJP.zip。