Additional file 1: of ErbB4 promotes malignant peripheral nerve sheath tumor pathogenesis via Ras-independent mechanisms
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Figure S1. ErbB4 lysates are sensitive to denaturing detergents. Table S1. Patient demographics for immunostained MPNSTs. Figure S2 Real-time PCR analyses of erbB4 splice variants and mouse MPNST erbB4 expression. Table S2. MPNST locations in P0-GGFβ3;Trp53+/â ;Erbb4flox/flox mice. Figure S3. Validation of Erbb4 ablation and effects on expression of other erbB receptors. Figure S4. Kinase array blots for NRG1β and unstimulated control and Erbb4-null MPNST cells. Figure S5. Downregulation of WNK1 expression did not affect cell viability. (ZIP 7528 kb)
补充图S1：表皮生长因子受体4（ErbB4）裂解物对变性去污剂敏感。 补充表S1：免疫染色的恶性周围神经鞘膜瘤（MPNST）患者人口统计学资料。 补充图S2：erbB4剪接变体的实时PCR（real-time PCR）分析及小鼠恶性周围神经鞘膜瘤（MPNST）中erbB4的表达情况。 补充表S2：P0-GGFβ3;Trp53+/−;Erbb4flox/flox小鼠的恶性周围神经鞘膜瘤（MPNST）发生部位。 补充图S3：Erbb4基因敲除验证及其对其他erbB受体表达的影响。 补充图S4：NRG1β刺激组、未刺激对照组及Erbb4敲除恶性周围神经鞘膜瘤（MPNST）细胞的激酶阵列印迹分析。 补充图S5：WNK1表达下调不影响细胞活力。 （压缩包，大小7528千字节）
