Supplementary Material for: Incidence of Stroke and Ischemic Stroke Subtypes: A Community-Based Study in Brno, Czech Republic

<b><i>Background:</i></b> There are few contemporary epidemiological data on stroke for Central Europe. We performed a population-based study evaluating the incidence of stroke, stroke types, and ischemic stroke (IS) subtypes in Brno, the second biggest city in the Czech Republic (CR). <b><i>Methods:</i></b> Using the National Registry of Hospitalized Patients, and hospital databases, we identified all patients hospitalized with a stroke diagnosis in Brno hospitals in 2011. For Brno residents with validated stroke diagnosis, we calculated (a) the overall incidence of hospitalized stroke, (b) incidence rates for IS, subarachnoid hemorrhage (SAH) and intracerebral hemorrhage (ICH), and (c) incidence rates for IS subtypes. We calculated the average annual age- and sex-standardized incidence (European Standard Population and World Health Organization), to compare our results with other studies. <b><i>Results:</i></b> The overall crude incidence of stroke in Brno was 213/100,000 population. The incidence of stroke for stroke types were as follows: SAH, 6.9; ICH, 26.4; and IS, 180 cases per 100,000 population, respectively. The WHO-standardized annual stroke incidence was 107 for all strokes and 88 for IS, 14.4 for ICH, and 5 for SAH. For IS subtypes, the WHO-standardized incidence was large artery atherosclerosis 25.8, cardioembolism 27.8, lacunar 21.6, other determined etiology 6.2, and undetermined etiology 6.5 cases per 100,000 population. <b><i>Conclusions:</i></b> The stroke incidence is lower than that previously reported for the CR and Eastern Europe probably reflecting socioeconomic changes in post-communistic countries in the region. These findings could contribute to stroke prevention strategies and influence health policies.

**背景：** 目前中欧地区卒中的当代流行病学数据较为匮乏。我们在捷克共和国（Czech Republic, CR）第二大城市布尔诺开展了一项基于人群的研究，对卒中发病率、卒中分型及缺血性卒中（ischemic stroke, IS）亚型分布情况进行评估。
**方法：** 依托国家住院患者登记系统与医院数据库，我们筛选出2011年布尔诺各医疗机构收治的所有卒中确诊病例。针对经确诊的布尔诺常住居民卒中患者，我们计算了以下三项指标：(a) 住院卒中总体发病率；(b) 缺血性卒中（IS）、蛛网膜下腔出血（subarachnoid hemorrhage, SAH）及脑出血（intracerebral hemorrhage, ICH）的发病率；(c) 缺血性卒中各亚型的发病率。我们采用欧洲标准人群与世界卫生组织（World Health Organization, WHO）标准进行年龄与性别标准化的年均发病率计算，以实现与其他研究结果的横向对比。
**结果：** 布尔诺地区卒中总体粗发病率为213/10万人口。各卒中分型的发病率分别为：蛛网膜下腔出血（SAH）6.9/10万、脑出血（ICH）26.4/10万、缺血性卒中（IS）180/10万人口。经世界卫生组织（WHO）标准化后，全卒中年均发病率为107/10万，缺血性卒中（IS）为88/10万，脑出血（ICH）为14.4/10万，蛛网膜下腔出血（SAH）为5/10万。针对缺血性卒中亚型，经WHO标准化后的发病率分别为：大动脉粥样硬化型25.8/10万、心源性栓塞型27.8/10万、腔隙性型21.6/10万、其他明确病因型6.2/10万及不明病因型6.5/10万人口。
**结论：** 本次研究测得的卒中发病率低于此前捷克共和国及东欧地区的相关报道，这可能与该地区后共产主义国家的社会经济变革相关。本研究结果可为卒中预防策略制定及卫生政策调整提供科学依据。