Audiological ototoxicity monitoring guidelines: a review of current evidence and appraisal of quality using the AGREE II tool

The effectiveness of audiological monitoring for detecting early hearing changes in patients receiving ototoxic medication could be limited by the lack of adequate audiological ototoxicity monitoring (OtoM) guidelines. This study aimed to evaluate existing OtoM guidelines using the AGREE II tool for guideline evaluation. Guideline Review. Three audiological OtoM guidelines. An online search identified three audiological OtoM guidelines published by the American Speech-Language and Hearing Association (ASHA), the American Academy of Audiology (AAA) and the Health Professionals Council of South Africa (HPCSA). Evaluation using the Appraisal of Guidelines for Research and Evaluation (AGREE) II tool found the HPCSA audiological OtoM guideline scored higher than the ASHA and AAA guidelines in five of the six tool domains. All guidelines received average domain ratings of less than 50% with each reviewer recommending all three guidelines for use following modification. The findings of this study could partly explain the poor uptake of audiological OtoM practices internationally, further investigation is needed to identify the specific factors limiting the implementation of audiological OtoM in clinical practice.

耳毒性药物治疗患者的早期听力变化检测中，听力监测的有效性可能因缺乏完善的耳毒性听力监测（OtoM）指南而受限。本研究旨在采用指南评价工具AGREE II，对现有的OtoM指南进行评估。指南综述。共纳入3项听力学OtoM指南。通过在线检索，共获取由美国言语语言听力协会（ASHA）、美国听力学学会（AAA）以及南非健康专业委员会（HPCSA）发布的3项听力学OtoM指南。采用研究与评价指南评估（AGREE）II工具进行评估后发现，在该工具的6个领域中，南非健康专业委员会发布的OtoM指南有5个领域的得分均高于美国言语语言听力协会与美国听力学学会发布的指南。所有指南的各领域平均评分均低于50%，但每位评审均建议在修订后采用这3项指南。本研究结果可在一定程度上解释国际范围内听力学OtoM实践普及率偏低的现状，未来仍需开展进一步研究，以明确限制临床实践中OtoM实施的具体因素。