Inhibition of UBE2N promoted the clearance of mutant huntingtin in HD knock-in mouse

Individual transcript analysis of subcluster-1 and subcluster-25 was performed using the heatmaps of differentially expressed genes (DEGs) from HD-/- negative (WT), vehicle-treated HD+/- (HD;Veh), and NSC697923-treated (HD;NSC) mice.The left panel displays the networks of KOG annotation analysis for DEGs in HD-/- negative mice (WT) compared to vehicle-administered HD+/- (HD;Veh) mice. The right panel illustrates the matched categorization between the HD;Veh group and NSC697923-treated HD+/- (HD;NSC) mice.The heatmaps display individual DEGs extracted from the KOG analysis of the "Posttranslational modify, protein turnover, chaperones" functional subcluster.