Copper homeostasis in Aspergillus fumigatus

The filamentous fungus Aspergillus fumigatus is the most important pathogenic fungus among Aspergillus species associated with aspergillosis. A. fumigatus is exposed to diverse environmental stresses in the hosts during infection, such as deprivation or excess of essential metal copper. To gain further insights into copper homeostasis, we generated an A. fumigatus laboratory evolved strain with increased fitness in copper stress, and identified the mutation in a Zn2-Cys6 type transcription factor clcA.丝状真菌烟曲霉（Aspergillus fumigatus）是曲霉属中与曲霉病（aspergillosis）相关的最重要致病真菌。在感染宿主的过程中，烟曲霉会遭遇多种环境胁迫，例如必需金属铜的匮乏或过量蓄积。为进一步阐明铜稳态（copper homeostasis）的调控机制，本研究构建了一株在铜胁迫环境中适应性提升的烟曲霉实验室进化菌株，并鉴定出Zn2-Cys6型转录因子（Zn2-Cys6 type transcription factor）clcA中的突变位点。