Association of domain-specific physical activity with nocturia: a population-based study

Nocturia is the most prevalent lower urinary tract symptom (LUTS) and is closely associated with various diseases and social burdens. Research on the relationship between physical activity and various diseases has progressed significantly. However, the association between nocturia and physical activity has received limited attention in prior studies. Thus，this study aimed to investigate the relationship between different domains of physical activity (e.g., occupation-related physical activity [OPA], transportation-related physical activity [TPA], and leisure-time physical activity [LTPA]) and nocturia. We included 5516 participants from the cross-sectional National Health and Nutrition Examination Survey (NHANES) conducted between 2007 and 2012，employing survey-weighted logistic regression, restricted cubic splines (RCS), subgroup analysis, and sensitivity analysis to assess the relationship between different domains of physical activity and nocturia.<b> </b>Multivariable logistic regression analysis revealed a significant negative correlation between PA, LTPA, and nocturia. Specifically, PA (OR: 0.7523, 95% CI: 0.6307–0.8974, P = 0.002) and LTPA (OR: 0.7664, 95% CI: 0.6314–0.9304, P = 0.007) were negatively associated with nocturia. The RCS curve demonstrated non-linear relationships between PA, LTPA, and nocturia. Additionally, subgroup analyses and sensitivity analyses further validated this association.<b> </b>Based on this cross-sectional study, we suggested that PA and LTPA are associated with a reduced risk of nocturia in adults aged 20 years and older in the United States. This underscoring the importance of physical activity in preventing and managing nocturia may provide valuable guidance for clinical practice.

夜尿症（Nocturia）是最常见的下尿路症状（lower urinary tract symptom, LUTS），与多种疾病及社会负担密切相关。当前关于身体活动与各类疾病关联的研究已取得显著进展，但此前针对夜尿症与身体活动关联的探索却较为有限。为此，本研究旨在探讨不同维度身体活动——例如职业相关身体活动（occupation-related physical activity, OPA）、交通相关身体活动（transportation-related physical activity, TPA）以及闲暇时间身体活动（leisure-time physical activity, LTPA）——与夜尿症之间的关联。本研究纳入2007至2012年开展的横断面全国健康与营养调查（National Health and Nutrition Examination Survey, NHANES）中的5516名参与者，采用调查加权logistic回归、限制性立方样条（restricted cubic splines, RCS）、亚组分析及敏感性分析，以评估不同维度身体活动与夜尿症的关联。

多因素logistic回归分析显示，总体身体活动（physical activity, PA）、闲暇时间身体活动与夜尿症存在显著负相关。具体而言，总体身体活动（比值比（odds ratio, OR）: 0.7523, 95%置信区间（confidence interval, CI）: 0.6307–0.8974, P=0.002）与闲暇时间身体活动（OR: 0.7664, 95%CI: 0.6314–0.9304, P=0.007）均与夜尿症呈负相关。限制性立方样条曲线揭示了总体身体活动、闲暇时间身体活动与夜尿症之间的非线性关联。此外，亚组分析与敏感性分析进一步验证了这一关联。

基于此项横断面研究，我们认为在美国20岁及以上成人群体中，总体身体活动与闲暇时间身体活动与夜尿症的发病风险降低相关。该研究凸显了身体活动在夜尿症预防与管理中的重要性，可为临床实践提供有价值的指导。