SIL+CdCl2+EtOH

The data sets show investigations into the effects of Silymarin (SIL) on testicular function and oxidative stress status of ethanol (EtOH) and cadmium chloride (CdCl2) treated rats. Sixty-six (66) adult male Wistar rats were randomly divided into 6 groups of equal animals, which includes control and experimental groups receiving SIL; EtOH; CdCl2; EtOH + SIL and CdCl2 + SIL. EtOH and CdCl2 caused significant decrease in sperm count, progressive motility, normal sperm cells and serum testosterone. There was also a significant reduction in superoxide dismutase, catalase and glutathione peroxidase levels while significant (p<0.05) increase in malonaldehyde (MDA) was observed in EtOH and CdCl2 treated rats. SIL consumption decreased the lipid peroxidation and increased testicular enzymatic antioxidants in the EtOH and CdCl2 treated rats. Semen parameters and testosterone in EtOH and CdCl2 treated rats were ameliorated following SIL consumption.

本数据集聚焦水飞蓟素（Silymarin, SIL）对乙醇（ethanol, EtOH）与氯化镉（cadmium chloride, CdCl2）染毒大鼠的睾丸功能及氧化应激状态的影响研究。研究选取66只成年雄性Wistar大鼠，随机均分为6组，涵盖对照组以及给予SIL、EtOH、CdCl2、EtOH+SIL、CdCl2+SIL的实验组。结果显示，EtOH与CdCl2染毒可显著降低大鼠精子数量、前向运动率、正常形态精子占比及血清睾酮水平；同时可显著下调超氧化物歧化酶、过氧化氢酶与谷胱甘肽过氧化物酶的活性，且染毒大鼠的丙二醛（malonaldehyde, MDA）水平显著升高（p<0.05）。经SIL干预后，EtOH与CdCl2染毒大鼠的脂质过氧化水平降低，睾丸组织抗氧化酶活性提升，精液参数与血清睾酮水平亦得到显著改善。