Botulinum toxin in the treatment of partially accommodative esotropia with high AC/A ratio

Purpose: To study the outcome of botulinum toxin (BTX) treatment (group 1) in partially accommodative esotropia with high accommodative convergence/accommodation (AC/A) ratio, in comparison with bilateral medial rectus muscles recessions and posterior fixation (group 2).

Methods: In a retrospective comparative study, children aged 3-8 years old treated between 2011 and 2016, with partially accommodative esotropia with high AC/A ratio, deviation at distance of 10 prism diopters or more, and at least 1 year of follow-up, were included. Visual acuity, alternate prism and cover test, stereoacuity, biomicroscopy, and cycloplegic retinoscopy were carried out at initial, baseline visit, 6 months and 1 year after BTX injection or surgery. Main outcome variables were deviation at distance and near, improvement in stereoacuity, and percentage of success. We used multiple regression or proportional odds analysis to control for potential confounding variables.

Results: Of 95 patients, 84 were...

研究目的：对比肉毒杆菌毒素（botulinum toxin, BTX）治疗组（组1）与双侧内直肌后退联合后固定术组（组2）在高调节性集合/调节（AC/A）比值的部分调节性内斜视中的治疗效果。
研究方法：本研究为回顾性对照研究，纳入2011至2016年间收治的3~8岁儿童患者，均符合以下纳入标准：患有高AC/A比值的部分调节性内斜视，远距离斜视度≥10三棱镜度，且随访时长至少1年。分别于治疗前初诊、基线访视，以及肉毒杆菌毒素注射或手术后6个月、1年时，对受试者开展视力检查、交替三棱镜遮盖试验、立体视锐度检测、裂隙灯生物显微镜检查及睫状肌麻痹验光。主要结局指标包括远距离与近距离斜视度、立体视锐度改善情况及治疗成功率。本研究采用多元回归分析或比例优势分析，以控制潜在混杂变量。
研究结果：共纳入95例患者，其中84例……