首页/数据集/Additional file 7 of NK-A 17E-233I: a novel competitive inhibitor of human dihydroorotate dehydrogenase (DHODH) for cancer therapy

Additional file 7 of NK-A 17E-233I: a novel competitive inhibitor of human dihydroorotate dehydrogenase (DHODH) for cancer therapy

NIAID Data Ecosystem2026-05-10 收录

DHODH抑制剂

抗癌药物研发

数据链接：

https://figshare.com/articles/dataset/Additional_file_7_of_NK-A_17E-233I_a_novel_competitive_inhibitor_of_human_dihydroorotate_dehydrogenase_DHODH_for_cancer_therapy/30390420 数据链接链接失效反馈

官方服务：

资源简介：

Supplementary Material 7.

补充材料7.

应用场景：

创建时间：

2025-10-17

抗癌药物研发

碳酸酐酶抑制剂

IntroductionMultitargeted anticancer agents can overcome resistance by simultaneously modulating key pathways. This study reports a novel thiazole -chalcone/sulfonamide hybrid (compound 7) designed to

NIAID Data Ecosystem20

Bifunctional Naphtho[2,3‑ d ][1,2,3]triazole-4,9-dione Compounds Exhibit Antitumor Effects In Vitro and In Vivo by Inhibiting Dihydroorotate Dehydrogenase and Inducing Reactive Oxygen Species Production

DHODH抑制剂

双功能抗肿瘤化合物

Human dihydroorotate dehydrogenase (hDHODH) is an attractive target for cancer therapy. Based on its crystal structure, we designed and synthesized a focused compound library containing the structural

NIAID Data Ecosystem20

Original 2‑(3-Alkoxy‑1 H ‑pyrazol-1-yl)azines Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH)

DHODH抑制剂

抗病毒药物发现

Following our discovery of human dihydroorotate dehydrogenase (DHODH) inhibition by 2-(3-alkoxy-1H-pyrazol-1-yl)pyrimidine derivatives as well as 2-(4-benzyl-3-ethoxy-5-methyl-1H-pyrazol-1-yl)-5-meth

NIAID Data Ecosystem10

Curcumin Analog DM-1 in Monotherapy or Combinatory Treatment with Dacarbazine as a Strategy to Inhibit In Vivo Melanoma Progression

黑色素瘤治疗

抗癌药物研发

Malignant melanoma is a highly aggressive form of skin cancer with a high mortality rate if not discovered in early stages. Although a limited number of treatment options for melanoma currently exist,

Figshare2016-01-15 更新20

Supplementary Table from Decreased DNA Damage and Improved p53 Specificity of RITA Analogs

p53特异性调控

抗癌药物研发

Supplementary Table from Decreased DNA Damage and Improved p53 Specificity of RITA Analogs

NIAID Data Ecosystem10