MOESM1 of MeDIP-seq and nCpG analyses illuminate sexually dimorphic methylation of gonadal development genes with high historic methylation in turtle hatchlings with temperature-dependent sex determination

Additional file 1. Table S1: Genes with distinct hypermethylated sex-specific windows within the same gene. Table S2: Categories enriched (p = 0.05) in hypermethylated genes at male-producing temperature (26 °C). Table S3: Categories enriched (p = 0.05) in hypermethylated genes at female-producing temperature (31 °C). Tables S4 through S11—differentially methylated genes in C. picta hatchling methylomes along with RPKM, fold change and edgeR p value: Table S4: Heat shock genes. Table S5: Androgen-/estrogen-related genes. Table S6: Kinases. Table S7: Histone-related genes. Table S8: Ubiquitin-related genes. Table S9: Transient receptor potential genes. Table S10: Genes involved in cell proliferation. Table S11: Germline-related genes. Table S12: Number of differentially methylated genes by GO term present in testis and ovaries of C. picta hatchlings. Table S13: Comprehensive list of differentially methylated genes and associated GO pathways between testis and ovaries of C. picta hatchlings. Table S14: Statistics of all differentially methylated genes between testis and ovaries of C. picta hatchlings. Table S15: Genes differentially expressed in the C. picta transcriptome (stage 22) [42] and differentially methylated in the hatchling methylome (this study). Table S16: Relative abundance distribution of repeat categories as a fraction of the genome. Table S17: Overlapping genes between C. picta hatchling methylomes and the methylomes of tongue sole [18].附加文件1。表S1：同一基因内存在特异性高甲基化性别特异性基因组窗口的基因。表S2：雄性发育温度（26℃）下高甲基化基因富集的功能类别（p=0.05）。表S3：雌性发育温度（31℃）下高甲基化基因富集的功能类别（p=0.05）。表S4至表S11：锦龟（C. picta）幼体甲基化组中的差异甲基化基因，附带RPKM、倍数变化及edgeR检验P值，具体如下：表S4：热休克基因；表S5：雄激素/雌激素相关基因；表S6：激酶类基因；表S7：组蛋白相关基因；表S8：泛素相关基因；表S9：瞬时受体电位基因；表S10：细胞增殖相关基因；表S11：生殖系相关基因。表S12：锦龟幼体睾丸与卵巢中，按GO功能注释条目（GO term）分类的差异甲基化基因数量。表S13：锦龟幼体睾丸与卵巢间差异甲基化基因及其关联GO通路（GO pathway）的完整列表。表S14：锦龟幼体睾丸与卵巢间所有差异甲基化基因的统计信息。表S15：锦龟22期转录组中差异表达，且本研究幼体甲基化组中存在差异甲基化的基因[42]。表S16：基因组重复序列类别的相对丰度分布（以基因组占比计）。表S17：锦龟幼体甲基化组与舌鳎甲基化组[18]中的重叠基因。