Site-Selective Rh-Catalyzed C‑7 and C‑6 Dual C–H Functionalization of Indolines: Synthesis of Functionalized Pyrrolocarbazoles

A site-selective
dual C-7 and C-6 C–H functionalization
of indolines with azabenzonorbornadienes has been accomplished using
Rh-catalysis. The reaction affords a potential route toward pyrrolocarbazoles
with broad scope and functional group tolerance.

本研究采用铑催化（Rh-catalysis）策略，成功实现了吲哚啉（indolines）与氮杂苯并降冰片二烯（azabenzonorbornadienes）之间的位点选择性双C-7及C-6位碳氢键（C–H）官能化反应。该反应为构建吡咯并咔唑（pyrrolocarbazoles）类化合物提供了一条底物适用范围宽泛、官能团耐受性优异的可行合成路径。