Demographics of study population.

PurposeTo assess long-time results of primary surgical treatment in children with glaucoma after congenital cataract surgery.MethodsA retrospective study of 37 eyes from 35 children with glaucoma after congenital cataract surgery, who underwent surgery between 2011 and 2021 at the Childhood Glaucoma Center, University Medical Center Mainz, Germany. Only children, who received a primary glaucoma surgery in our clinic within the given time (n = 25) and had at least one-year follow-up (n = 21), were included in the further analysis. The mean follow-up time was 40.4±35.1 months. The primary outcome was the mean reduction in IOP (in mmHg) from baseline to follow-up visits after the surgery, measured with Perkins tonometry.Results8 patients (38%) were treated with probe trabeculotomy (probe TO), 6 (29%) with 360° catheter-assisted trabeculotomy (360° TO) and 7 (33%) with cyclodestructive procedures. IOP was significantly reduced after probe TO and 360° TO after 2 years, from 26.9 mmHg to 17.4 mmHg (pConclusionsIn glaucoma after congenital cataract surgery, both trabeculotomy techniques, lead to good reduction of IOP after 2 years. There is a need for a prospective study with comparison to the use of glaucoma drainage implants.研究目的 评估先天性白内障术后儿童青光眼患者接受首次手术治疗的长期疗效。 研究方法 本回顾性研究纳入2011年至2021年间，于德国美因茨大学医学中心儿童青光眼中心接受治疗的35例儿童（共37眼）先天性白内障术后青光眼患者。仅纳入在指定时间段内于本诊所接受首次青光眼手术且随访时长至少1年的受试者（共25例，最终纳入进一步分析者21例）。本研究平均随访时长为40.4±35.1个月。主要结局指标为采用Perkins眼压计（Perkins tonometry）测量的、手术基线至术后随访访视时的眼压（intraocular pressure, IOP，单位为mmHg）的平均降幅。 研究结果 8例患者（38%）接受了探针小梁切开术（probe trabeculotomy, probe TO）治疗，6例（29%）接受了360°导管辅助小梁切开术（360° catheter-assisted trabeculotomy, 360° TO），7例（33%）接受了睫状体破坏性手术。术后2年时，探针小梁切开术与360°导管辅助小梁切开术组的眼压均显著降低，从26.9 mmHg降至17.4 mmHg（p）。 研究结论 针对先天性白内障术后青光眼患者，两种小梁切开术术式均可在术后2年实现良好的眼压控制效果。未来需开展前瞻性研究，与青光眼引流植入物（glaucoma drainage implants）的应用效果进行对比。