Spatial and Single Cell Mapping of Castleman Disease Reveals Key Stromal Cell Types and Cytokine Pathways

multiplexed imaging of 40+ protein targets across human lymph node. single nuclei RNA-seq of the same tissues. Spatial gene expression through the Xenium platform of lymph node core biopses.

针对人淋巴结内40余种蛋白质靶标开展多重成像（multiplexed imaging）检测；对同一组织进行单细胞核RNA测序（single nuclei RNA-seq）；通过Xenium平台对淋巴结核心活检标本进行空间基因表达分析。