Genetic differences in physiological and subjective effects after MDMA administration (mean ± SD; women n = 12 vs. men n = 15) (only significant effects included).

AUC: area under the effect-time curve; Emax: peak effect; COMT, catechol-O-methyltransferase; SBP: systolic blood pressure; DBP: diastolic blood pressure. 5-HTTLPR, gene-linked polymorphic region VESSPA: Evaluation of the Subjective Effects of Substances with Abuse Potential.
*p<0.05;
**p<0.01. N = [COMT, valval n = 8 vs. met/* n = 18; 5-HTTLPR, l/* n = 18 vs. s/s n = 9.

AUC：效应-时间曲线下面积（area under the effect-time curve, AUC）；Emax：最大效应（peak effect, Emax）；COMT：儿茶酚-O-甲基转移酶（catechol-O-methyltransferase, COMT）；SBP：收缩压（systolic blood pressure, SBP）；DBP：舒张压（diastolic blood pressure, DBP）。5-HTTLPR：5-羟色胺转运体基因连锁多态区（gene-linked polymorphic region, 5-HTTLPR）；VESSPA：物质滥用潜能主观效应评估（Evaluation of the Subjective Effects of Substances with Abuse Potential, VESSPA）。
*p<0.05；**p<0.01。N = [COMT分型：valval基因型n=8 vs. met/*基因型n=18；5-HTTLPR分型：l/*基因型n=18 vs. s/s基因型n=9]