Innate immune specificity in copepod-tapeworm system. Macrocyclops albidus

We present Illumina-generated RNASeq data from a system consisting the copepod Macrocyclops albidus and its natural parasite, the tapeworm Schistocephalus solidus, in which a high degree of innate immune specificity was observed for the first time. Using homologous (same family) vs. heterologous (unrelated) priming-challenge procedures, we first show that copepods exposed to the same parasite family benefit from reduced secondary infections. We then focused on exposed-but-not-infected copepods in the first exposure to use a transcriptome method to discriminate between immunity that was either specific or unspecific in terms of tapeworm type discrimination.

本研究公开了由Illumina公司生成的RNA测序（RNASeq）数据，样本取自以桡足类动物白近剑水蚤（Macrocyclops albidus）及其天然寄生虫绦虫（Schistocephalus solidus）构建的宿主-寄生虫系统，该系统中首次观测到了极高程度的先天免疫特异性。本研究采用同源（同科）与异源（无亲缘关系）预刺激-攻击实验方案，首先证实暴露于同科寄生虫的桡足类可获得继发性感染减轻的保护效应。随后，本研究针对首次暴露后未被感染的桡足类样本，运用转录组学方法，区分基于绦虫类型识别的特异性免疫与非特异性免疫应答。