Wild-type p53 binds to the TATA-binding protein and represses transcription.
收藏PubMed Central1992-12-15 更新2026-05-16 收录
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https://pmc.ncbi.nlm.nih.gov/articles/PMC50691/
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资源简介：
p53 activates transcription of genes with a p53 response element, and it can repress genes lacking the element. Here we demonstrate that wild-type but not mutant p53 inhibits transcription in a HeLa nuclear extract from minimal promoters. Wild-type but not mutant p53 binds to human TATA-binding protein (TBP). p53 does not bind to yeast TBP, and it cannot inhibit transcription in a HeLa extract where yeast TBP substitutes for human TBP. These results suggest a model in which p53 binds to TBP and interferes with transcriptional initiation. IMAGES:
提供机构：
National Academy of Sciences
创建时间：
1992-12-15
