Metadata record for the manuscript: Ivermectin converts cold tumors hot and synergies with immune checkpoint blockade for treatment of breast cancer

Summary This metadata record provides details of the data supporting the claims of the related manuscript: “Ivermectin converts cold tumors hot and synergies with immune checkpoint blockade for treatment of breast cancer ”. The related study shows that treatment with the FDA-approved anti-parasitic drug ivermectin induces immunogenic cancer cell death (ICD) and robust T cell infiltration into breast tumours. Type of data: tumour size measurements, flow cytometry, histology Subject of data: 4T1 cell line, BALB/c (Mus musculus) Data access The flow cytometry data (fluorescence-activated cell sorting--FACS) are available upon request from the corresponding author. Other data generated as part of the related study are tumour size measurements and histology. These are available upon request from the corresponding author. Corresponding author(s) for this study Peter P. Lee, M.D., Dept. of Immuno-Oncology, City of Hope and Beckman Research Institute, Beckman Center, room 5117, 1500 East Duarte Road, Duarte, CA 91010. Email: [e-mail]. Study approval All procedures were performed under approval from City of Hope’s Animal Care and Use Committee.本元数据记录详细阐明了支撑相关研究论文《伊维菌素将冷肿瘤转化为热肿瘤并与免疫检查点阻断疗法协同治疗乳腺癌》核心主张的配套实验数据。该项研究证实，经美国食品药品监督管理局（Food and Drug Administration, FDA）批准的抗寄生虫药物伊维菌素，可诱导肿瘤细胞发生免疫原性细胞死亡（immunogenic cancer cell death, ICD），并有效促进T细胞向乳腺癌肿瘤组织中浸润。 数据类型：肿瘤体积测量数据、流式细胞术数据、组织病理学数据 数据对象：4T1细胞系、BALB/c小鼠（小家鼠 *Mus musculus*） 数据获取方式：流式细胞术数据（即荧光激活细胞分选技术，fluorescence-activated cell sorting, FACS）可向通讯作者申请获取。本项研究产生的其余配套数据包括肿瘤体积测量数据与组织病理学数据，均可向通讯作者申请获取。 本研究通讯作者：彼得·P·李（Peter P. Lee）医学博士，美国希望之城与贝克曼研究所免疫肿瘤学系，地址：加利福尼亚州杜阿尔特市东杜阿尔特路1500号贝克曼中心5117室，电子邮箱：[e-mail]。 研究伦理审批：所有实验操作均已获得希望之城动物护理与使用委员会的批准许可。