Epigenetic Impact of Long-Term Shiftwork: Poly Evidence from Cricadian Genes and Whole-Genome Methylation Analyses

Analysis of genomic methylation differences between day workers and shift workers. We hypothesized that there would be differences in methylation patterns between day workers and shift workers, and that some of these differences may explain the association between long-term shift work and breast cancer. The array provides methylation data on more than 27,000 CpG sites spread across the genome. Bisulfite-converted DNA from 10 day workers and 10 shift workers were hybridised to the Illumina Infinium 27k Human Methylation Beadchip v1.2.

本数据集针对白班工作者与轮班工作者之间的基因组甲基化差异展开分析。本研究假设两类人群的甲基化模式存在差异，且部分此类差异可解释长期轮班工作与乳腺癌之间的关联。该芯片提供了覆盖全基因组的27000余个CpG位点（CpG site）的甲基化数据。本研究提取10名白班工作者与10名轮班工作者的亚硫酸氢盐转化DNA，并将其与Illumina Infinium 27k人类甲基化微珠芯片v1.2进行杂交。