Tryptamine induced metabolic alterations of prostate cancer in vitro and in vivo

Tryptamine is the most important compound of the indoleamine family, and its scaffold has been applied in the design of pharmacological agents with anti-migraine, antibacterial and antitumor effects . tryptamine had a stronger inhibitory effect on high metastatic PCa cell line PC-3 and low metastatic PCa cell line LNCaP compared to the normal prostate epithelial cell line RWPE-1. It also shown to induce cell apoptosis and could markedly inhibit cell migration of PC-3.Metabolic changes induced by tryptamine treatment of PC-3 cells and tumor xenograft mice were also analyzed, with differential metabolites involved in amino acid metabolism and related to prostate cancer development and metastasis identified.

色胺（Tryptamine）是吲哚胺家族中至关重要的化合物，其母核骨架已被应用于具有抗偏头痛、抗菌及抗肿瘤活性的药理活性分子设计。相较于正常前列腺上皮细胞系RWPE-1，色胺对高转移性前列腺癌（PCa）细胞系PC-3与低转移性前列腺癌细胞系LNCaP的抑制作用更强。研究表明，色胺可诱导细胞凋亡，并能显著抑制PC-3细胞的迁移能力。本研究还分析了色胺处理PC-3细胞及肿瘤异种移植小鼠后所引发的代谢变化，鉴定出了参与氨基酸代谢、且与前列腺癌发生及转移相关的差异代谢物。