PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane

Characterization of human INPP5F (SAC2) identified that it is a 4-phosphatase with highest activity against PI(4,5)P2, PI(3,4)P2, and PI(3,4,5)P3, generating PI(5)P, PI(3)P and PI(3,5)P2 respectively (Nakatsu et al. 2015, Hsu et al. 2015). Inpp5f -/- mice have elevated level of PIP3 and exhibit accentuated cardiac hypertrophy as measured by heart size, myocyte size and gene expression (Zhu et al. 2009).

对人INPP5F（SAC2）的表征研究表明，其是一种以PI(4,5)P2、PI(3,4)P2和PI(3,4,5)P3为底物的4-磷酸酶，活性最高，分别生成PI(5)P、PI(3)P和PI(3,5)P2（Nakatsu等人，2015年，Hsu等人，2015年）。INPP5f-/-小鼠的PIP3水平升高，表现为心脏肥厚程度加剧，以心脏大小、心肌细胞大小和基因表达作为衡量指标（Zhu等人，2009年）。