Gene expression analysis of HdhQ111 mice in a Pin1 knock-out background. Mus musculus

we report additional phenotypes of mHtt mice that are modified in Pin1 knock-out mice Overall design: RNAs from the striatum of three mice of 12 months of age were purified for each of the genotypes (PinWT/HttWT; PinKO/HttWT; PinWT/HttKI; PinKO/HttKi) to carry out gene expression profiling

本研究报道了Pin1敲除（Pin1 knock-out，PinKO）背景下的突变型亨廷顿蛋白（mHtt）小鼠的额外表型。实验设计概述：针对四种基因型（PinWT/HttWT、PinKO/HttWT、PinWT/HttKI、PinKO/HttKi），分别提取12月龄三只小鼠的纹状体RNA以开展基因表达谱分析。