Detection of APOBEC3B-mediated RNA editing sites in 293T cells

RNA editing is an important post-transcriptional modification that contributes to proteomic diversity and gene expression regulation. In this project, we utilize RNA sequencing (RNA-seq) data from the 293T cell line, a widely used human embryonic kidney cell line, to investigate RNA editing events. This dataset is part of a larger study aimed at mapping RNA editing sites through the integration of both RNA and DNA sequencing data. The RNA-seq data specifically provides critical insights into the extent and impact of RNA editing on gene expression, shedding light on the molecular mechanisms within the 293T cell line and contributing to a broader understanding of post-transcriptional gene regulation.

RNA编辑（RNA editing）是一类重要的转录后修饰方式，可提升蛋白质组多样性并参与基因表达调控。本研究使用广泛应用的人胚肾细胞系293T的RNA测序（RNA-seq）数据，对RNA编辑事件进行探究。本数据集隶属于一项通过整合RNA与DNA测序数据以绘制RNA编辑位点图谱的大型研究。该RNA-seq数据可针对性地揭示RNA编辑对基因表达的影响程度与作用机制，有助于阐明293T细胞系内的分子调控过程，同时为全面理解转录后基因调控机制提供助力。