HGDS Hepatitis C_Rubella Dataset in Hemophilia Growth and Development Study

Laboratory results from hepatitis C and rubella assays
Study Description
A multicenter study of hemophilia and its complications, HGDS was established in 1988. Data were prospectively collected in 14 US hemophilia treatment centers through 1996/97. The HGDS investigated the effects of hemophilia and HIV on physical growth and maturation; immunological, neurological, and neuropsychological functioning; and the pathophysiology of HIV and hepatitis C. Research using the clinical data and stored samples continues and includes the genetic research that paved the way for development of the protease inhibitors currently used to treat HIV; studies that provided clues to viral characteristics of HIV and hepatitis B and C; research to identify genetic factors associated with the development of inhibitory antibodies to factor VIII; the relationship of inhibitors to cognitive development and academic achievement; studies of viral factors and how they relate to progression of HIV and hepatitis C; and research on the parenteral transmission of human viruses. Biospecimens are available. Children and adolescents ages 6 to 19 with hemophilia (n=333), with and without HIV infection, and a subset of their unaffected male siblings (n=47)

丙型肝炎（hepatitis C）与风疹（rubella）检测的实验室结果
研究概况
本研究为针对血友病（hemophilia）及其并发症的多中心研究项目HGDS，于1988年启动。研究数据于1988年至1996/1997年间，在美国14家血友病治疗中心前瞻性采集完成。
HGDS的研究内容涵盖：血友病与人类免疫缺陷病毒（HIV）对个体体格生长与发育、免疫功能、神经系统及神经心理学功能的影响，以及HIV与丙型肝炎的病理生理学机制。
基于该临床数据与留存生物样本（biospecimens）的后续研究仍在持续开展，涵盖以下方向：为当前临床治疗HIV所用的蛋白酶抑制剂（protease inhibitors）研发奠定基础的遗传学研究；揭示HIV、乙型肝炎（hepatitis B）与丙型肝炎病毒特征的相关研究；探寻与凝血因子VIII（factor VIII）抑制性抗体产生相关的遗传因素的研究；抑制性抗体与认知发育及学业成就之间关联的研究；病毒因子及其与HIV、丙型肝炎病情进展相关性的研究；以及人类病毒经肠外传播（parenteral transmission）的相关研究。
该数据集提供留存生物样本。
研究对象为6至19岁的血友病患儿及青少年（共333例），其中部分合并HIV感染，部分未合并；同时纳入其未受影响的男性同胞亚组（共47例）。