On the Effect of Temperature on Aqueous Solubility of Organic Solids

The variation of solubility with temperature in water is an important consideration in the design of crystallizations and other processes. Solubility was found to vary exponentially with temperature (in °C) for a literature data set of 50 organic molecules in water. This complements a similar recent finding for the solubility of organic molecules in organic solvents. The ‘solubility doubling temperature’ is a convenient way to express this variation and provides a numerical link between enthalpy of dissolution and yield. The ‘solubility doubling temperature’ in water varies with solute, and the median value from this data set is 21.4 °C, consistent with ‘Black’s rule’.

水溶液中溶解度随温度的变化规律，是结晶工艺及其他相关过程设计中的重要考量因素。针对包含50种水溶液中有机分子的文献数据集，研究发现其溶解度随温度（单位：℃）呈指数变化规律。这一发现补充了近期有关有机溶剂中有机分子溶解度的同类研究结论。溶解度倍增温度（solubility doubling temperature）是表征该变化规律的简便方式，同时可建立溶解焓与产率之间的数值关联。水溶液中的溶解度倍增温度因溶质不同而异，本数据集的中位数为21.4℃，与布莱克规则（Black’s rule）相符。