Quantitative protein profiling of brain vessels in rhesus macaque

Aging is a major risk factor for cerebrovascular disease. However, the molecular mechanisms of cerebrovascular aging remain to be clarified. In this study, we performed proteomics analysis aimed to reveal the molecular signaling pathways during aging.our study demonstrated that the imbalance of vasodilators and vasoconstrictors caused by downregulation of NOS3, oxidative stress mediated by the suppression of NRF2 pathway, and miRNA-regulated accumulation of ECM proteins were critical for cerebrovascular aging.

衰老是脑血管疾病的主要危险因素。然而，脑血管衰老的分子机制仍有待阐明。本研究开展蛋白质组学分析，旨在揭示衰老过程中的分子信号通路。研究证实，由内皮型一氧化氮合酶（NOS3）下调引发的血管舒张因子（vasodilators）与血管收缩因子（vasoconstrictors）失衡、由核因子E2相关因子2（NRF2）通路抑制介导的氧化应激，以及受微小RNA（miRNA）调控的细胞外基质（ECM）蛋白积累，均对脑血管衰老至关重要。