The Netherlands BAG

The Netherlands BAG includes groups situated at five Dutch universities (Utrecht, Groningen, Amsterdam, Wageningen and Eindhoven) and at the Netherlands Cancer Institute in Amsterdam, with a total of twelve PIs. The structural biology research carried out in these groups is highly diverse, including prokaryotic and eukaryotic proteins with a strong focus on targets and processes of biomedical relevance. Central to many projects are protein receptors and their interactions with other proteins and with small molecule modulators. An additional major research area concerns structure-based protein engineering and design aiming at the characterization and engineering of new enzymes for green chemistry and new-to-nature reactions. Projects deal with membrane and soluble proteins, cell surface receptors, and protein-protein, protein-ribonucleotide, protein-drug and enzyme-ligand complexes.

荷兰BAG数据集的研究团队依托荷兰5所大学（乌得勒支大学、格罗宁根大学、阿姆斯特丹大学、瓦赫宁根大学与埃因霍温大学）以及阿姆斯特丹的荷兰癌症研究所组建，共计12名首席研究员（Principal Investigators，PI）。该团队的结构生物学研究方向多元丰富，涵盖原核与真核蛋白质，且重点聚焦于具有生物医学价值的靶点与生物学过程。诸多项目的核心研究对象为蛋白质受体，及其与其他蛋白质、小分子调节剂的相互作用。另一核心研究领域为基于结构的蛋白质工程与设计，旨在为绿色化学及非天然反应表征并改造新型酶类。研究项目涵盖膜蛋白与可溶性蛋白、细胞表面受体，以及蛋白质-蛋白质、蛋白质-核糖核苷酸、蛋白质-药物与酶-配体复合物。