Associations between lifetime agoraphobia status at baseline and inflammatory measures (C-reactive protein) at follow-up, serially adjusted for covariates.

Values for inflammatory measures are given as unadjusted log10-transformed means ± standard deviation, values for interleukin-1β are given as prevalence.HDL, high-density lipoprotein; CRP, C-reactive protein; TNF, tumor necrosis factor; OR, odds ratio; 95CI, 95% confidence interval.a Duration between somatic evaluation at baseline and somatic evaluation at follow-up.b A value of “3” represents an SES of III (middle class) on the Hollingshead Scale.c Systolic blood pressure ≥ 140 mmHg and/or diastolic blood pressure ≥ 90 mmHg.d Physically active at least or more than 20 minutes twice a week.e Generalized anxiety disorder, panic disorder, posttraumatic stress disorder, and/or social phobia.f Marijuana, cocaine, solvent, hallucinogen, stimulant, sedative or/and narcotic dependence.g Multiple regression with log10-transformed cytokine or CRP or adiponectin.h Logistic regression with interleukin-1β concentration dichotomized at the median.i Composite score of inflammatory markers includes CRP, interleukin-6 and TNF-α. Only participants who had data available for all three of these markers were included in these analyses.Associations between lifetime agoraphobia status at baseline and inflammatory measures (C-reactive protein) at follow-up, serially adjusted for covariates.炎症指标（inflammatory measures）的取值以未经校正的log₁₀转换均值±标准差呈现，白细胞介素-1β（interleukin-1β）的取值以患病率表示。高密度脂蛋白（high-density lipoprotein，HDL）、C反应蛋白（C-reactive protein，CRP）、肿瘤坏死因子（tumor necrosis factor，TNF）、比值比（odds ratio，OR）、95%置信区间（95% confidence interval，95CI）。 a 基线躯体评估与随访躯体评估之间的间隔时长。 b 取值为"3"代表霍林斯海德量表（Hollingshead Scale）中的III级社会经济地位（SES，即中产阶级）。 c 收缩压≥140mmHg且/或舒张压≥90mmHg。 d 每周至少进行两次、每次时长不少于20分钟的身体活动。 e 广泛性焦虑障碍、惊恐障碍、创伤后应激障碍及/或社交恐惧症。 f 大麻、可卡因、溶剂、致幻剂、兴奋剂、镇静剂及/或麻醉剂依赖。 g 针对经log₁₀转换的细胞因子、C反应蛋白或脂联素（adiponectin）开展的多元回归分析。 h 以中位数为截点将白细胞介素-1β浓度二分类后实施的logistic回归分析。 i 炎症标志物综合评分涵盖C反应蛋白、白细胞介素-6及肿瘤坏死因子-α。仅纳入三项指标数据均完整的受试者开展此类分析。 本研究分析了基线时终身广场恐怖症（agoraphobia）患病状态与随访时炎症指标（C反应蛋白）之间的关联，并依次针对协变量进行校正。