Depletion of CD4 T Cells Does Not Equalize Spinal Cord Titers of 27 gfp Compared to 27US11 or 27m152, Whereas Depletion of CD8 T Cells Does
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https://figshare.com/articles/dataset/Inhibition_of_MHC_Class_I_Is_a_Virulence_Factor_in_Herpes_Simplex_Virus_Infection_of_Mice/153122
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BALB/c mice were either (A) untreated; or (B) and (C) treated 3 and 2 days before the time of infection with 200 μg α-CD4 MAb (GK1.5) or α-CD8 MAb (53–6.7), respectively. Mice were infected with 2.5 × 105 pfu of 27 gfp, 27US11, or 27m152 on day 0, and footpads and spinal cord were harvested on day 6. This experiment was distinct from the experiments shown in Figures 6 and 7, but the findings for A and C are similar to those shown in Figures 6A and 7C, respectively.
(357 KB EPS)
BALB/c小鼠分为三组：(A) 未处理对照组；(B)、(C)两组分别于感染前3天、感染前2天，以200 μg抗CD4单克隆抗体（α-CD4 MAb，GK1.5）、抗CD8单克隆抗体（α-CD8 MAb，53–6.7）进行处理。于第0天，以2.5×10^5 噬斑形成单位（plaque-forming unit，pfu）的27gfp、27US11或27m152毒株感染小鼠，并于第6天采集其足垫与脊髓组织。本实验与图6、图7所示实验存在差异，但(A)组与(C)组的实验结果分别与图6A、图7C所示结果相似。（357 KB EPS）
创建时间：
2013-01-20
