Crystal structure of an enoyl-[acyl-carrier-protein] reductase InhA from Mycobacterium fortuitum bound to NAD and NITD-916

Crystal structure of an enoyl-[acyl-carrier-protein] reductase InhA from Mycobacterium fortuitum bound to NAD and NITD-916 Descriptor: 6-[(4,4-dimethylcyclohexyl)methyl]-4-hydroxy-3-phenylpyridin-2(1H)-one, CHLORIDE ION, Enoyl-[acyl-carrier-protein] reductase [NADH], ... Authors: Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2022-02-18 Release date: 2023-02-22 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.05 Å) Cite: In Vitro and In Vivo Efficacy of NITD-916 against Mycobacterium fortuitum. Antimicrob.Agents Chemother., 67, 2023

偶发分枝杆菌（Mycobacterium fortuitum）来源的烯酰-[酰基载体蛋白]还原酶InhA与烟酰胺腺嘌呤二核苷酸（NAD）及NITD-916结合的晶体结构
组分描述：6-[(4,4-二甲基环己基)甲基]-4-羟基-3-苯基吡啶-2(1H)-酮、氯离子、烯酰-[酰基载体蛋白]还原酶[NADH]等
作者：西雅图传染病结构基因组学中心（Seattle Structural Genomics Center for Infectious Disease, SSGCID）
提交日期：2022-02-18
发布日期：2023-02-22
最后修改日期：2023-10-25
实验方法：X射线衍射（分辨率2.05埃）
引用文献：《NITD-916对抗偶发分枝杆菌的体外与体内药效研究》，《抗菌剂与化疗（Antimicrob. Agents Chemother.）》，67卷，2023年