IBS BAG

The IBS BAG currently includes 24 IBS teams and 4 external groups from CERMAV and iRTSV/CEA (Grenoble), CEA-Cadarache (St Paul lez Durance) and IRBA (Brétigny-sur-Orge). We study structure-function relationships of proteins emphasizing in human health, biotechnology and methodology. Most of the projects can be grouped in different topics as follows: host-pathogen interaction, immunology, new drug targets, fundamental cellular mechanisms, membrane proteins, intrinsically disordered proteins, biotechnological applications and methodology. Some of these projects use integrative approaches (X-ray crystallography, SAXS, NMR (and cryo-EM), together with other biophysical studies) with the aim to fully understand the complexity of the biological macromolecular systems on study. Some other teams are dedicated to serial crystallography and its developments, for which the new ESRF-EBS might be the perfect tool.

本IBS BAG目前涵盖24个IBS研究团队，以及来自法国格勒诺布尔的CERMAV与iRTSV/CEA、圣保罗莱迪朗斯的CEA-Cadarache，以及布里蒂尼叙尔奥尔日的IRBA的4个外部研究组。团队重点围绕人类健康、生物技术与方法学三大方向，开展蛋白质结构与功能关系的研究。绝大多数项目可归类为以下主题：宿主-病原体相互作用、免疫学、新型药物靶点、基础细胞机制、膜蛋白、内在无序蛋白质（intrinsically disordered proteins）、生物技术应用及方法学研究。部分项目采用整合研究策略，结合X射线晶体学、小角X射线散射（SAXS）、核磁共振（NMR）与冷冻电镜（cryo-EM）等生物物理研究手段，旨在全面解析所研究生物大分子系统的复杂性。另有部分团队专注于连续晶体学及其技术发展，而新型ESRF-EBS或将成为该领域的理想工具。