Estimated tumor growth parameters.

The kinetic model (Equations. (C1) and (C2)) was applied first to the untreated control tumor data, and the growth parameters ε, μ, b, d, and K0 (initial value of K) were solved for by performing gradient-based optimization for 1,000 randomly chosen set of initial parameters. Using obtained parameters the data for Bevacizumab (2 or 4 mg/kg) was used to solve for the respective treatment parameters e and clr in case of the original model (Equations. (C1) and (O1)) and the modified model (Equations. (C1) and (M1)).Estimated tumor growth parameters.