Estimated tumor growth parameters.

The kinetic model (Equations. (C1) and (C2)) was applied first to the untreated control tumor data, and the growth parameters ε, μ, b, d, and K0 (initial value of K) were solved for by performing gradient-based optimization for 1,000 randomly chosen set of initial parameters. Using obtained parameters the data for Bevacizumab (2 or 4 mg/kg) was used to solve for the respective treatment parameters e and clr in case of the original model (Equations. (C1) and (O1)) and the modified model (Equations. (C1) and (M1)).Estimated tumor growth parameters.

首先将动力学模型（kinetic model，式(C1)与式(C2)）应用于未处理的对照肿瘤数据集，随后通过对1000组随机选取的初始参数集执行基于梯度的优化，求解得到生长参数ε、μ、b、d以及K0（K的初始值）。基于上述求得的参数，分别针对原始模型（式(C1)与式(O1)）和改进模型（式(C1)与式(M1)），使用贝伐珠单抗（Bevacizumab，剂量为2或4 mg/kg）对应的数据集求解对应的治疗参数e与clr。肿瘤生长参数估算。